Minitab does not include an application for a time series analysis that uses covariates or regression involving correlated time series errors.
However, you can use Minitab to analyze the data described. For example, if the model specified is:
Yt = a0 + a1 X1t + a2 X2t + Et where Yt is the response variable, X1t, X2t are the dependent variables, and Et is the time series.