Use Power and Sample Size for 2x2 Crossover Design Equivalence Test to examine the relationship between power, sample size, and difference when you want to evaluate the equivalence of a test drug and a reference drug using a 2x2 crossover study.
For example, an analyst plans a 2x2 crossover study to determine whether a generic antacid is equivalent to a name-brand antacid. Two groups of participants will receive a 5-day course of one antacid, followed by a 2-week washout period, and then a 5-day course of the other antacid. Each group will be given the antacids in a different sequence.
Before initiating the study and collecting data, the analyst uses a power and sample size calculation to determine the number of participants that are needed in each sequence of the study to obtain a power of 80% (0.8).
To perform a power and sample size calculation for an equivalence test for a 2x2 crossover design, choose.