Find definitions and interpretation guidance for every graph that is provided with the equivalence test for a 2x2 crossover design.

An equivalence plot displays the equivalence limits, the confidence interval for equivalence, and the decision about whether you can claim equivalence.

Use the equivalence plot to view a graphical summary of the equivalence test results and to determine whether you can claim equivalence.

Compare the confidence interval with the equivalence limits. If the confidence interval is completely within the equivalence limits, you can claim that the mean of the test population is equivalent to the mean of the reference population. If part of the confidence interval is outside the equivalence limits, you cannot claim equivalence.

Shows the response to the reference treatment and the test treatment for each participant in the study. One plot is shown for each sequence in the study.

Use the subject profile plot to examine the responses of each participant to the test treatment and the reference treatment.

Compare the responses of the subjects in each sequence. Verify that the overall pattern is consistent with the equivalence test results. Identify any subjects whose response is markedly inconsistent with the other responses, which could affect the overall results.

The period plot shows Period 1 responses on the x-axis plotted against Period 2 responses on the y-axis. Each sequence is represented by a different symbol. The diagonal line shows where the x-values and the y-values are equal, for example, where x = 4 and y = 4.

Use the period plot to look for evidence of treatment effects, period effects, and sequence effects.

Look for the following patterns.

- Most points for one sequence are above the line and most points for the other sequence are below the line
- This pattern indicates a possible treatment effect. The response to the test treatment is different than the response to the reference treatment.
- Most points for one sequence appear in the lower left of the graph and most points for the other sequence appear in the upper right of the graph
- This pattern indicates a possible sequence effect. The responses are generally higher for one sequence than for the other sequence.
- Most points for both sequences appear on the same side of the line
- This pattern indicates a possible period effect. The responses are generally higher for one period than for the other period.
- The points for both sequences are scattered randomly on the graph
- This pattern indicates that there is no effect of treatment, sequence, or period. The responses are generally the same regardless of these factors.

The sequence by period mean plot shows the mean response for each period of each sequence.

Use the sequence by period mean plot to compare the mean response for the reference treatment and test treatment in each period of each sequence.
###### CAUTION

The means shown in the plot are based on samples rather than on entire populations. To determine whether any effects are statistically significant, examine the p-values in the Effects table. For more information, go to Effects for Equivalence Test for a 2x2 Crossover Design and click P-value for the effects.