If your data for the two sequences are stacked, with one column for the period 1 responses, one column for the period 2 responses, and another column to identify the sequence, complete the following steps.
In this worksheet, Period 1 contains the response data for the test and reference treatments in period 1. Period 2 contains the response data for the test and reference treatments in period 2. Sequence identifies the sequence for each response value. The reference, test treatment order was used in sequence 1. Therefore, the values in Period 1 represent the reference drug for sequence 1 and the test drug for sequence 2.