Cube plots can be used to show the relationships between two to eight factors with or without a response measure for 2-level factorial designs or Plackett-Burman designs. Viewing the factors without the response lets you to see what a design looks like. If there are only two factors, Minitab displays a square plot. You can draw a cube plot for either data means or fitted means.
The means of the raw response variable data for each factor level combination
After analyzing the design, the fitted means are the predicted values for each factor level combination. To plot the fitted means, you must fit the full model.
Although you can use these plots to compare effects, be sure to evaluate significance by examining the effects in the analysis of variable table.